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KMID : 1007520140230062063
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Food Science and Biotechnology
2014 Volume.23 No. 6 p.2063 ~ p.2068
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Alleviating Effects of Opuntia ficus indica Extracts on Psychomotor Alterations Induced by Ethanol in Rats
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Irene Joy I. dela Pena
Yoon Seo-Young
Kim Hee-JIn
Shim Hong
Kim Ji-Hyoung
Cheong Na-Rae
Paek Se-Hee
Seo Yong-Ki
Park Seok-Jun
Moon Byoung-Seok
Cheong Jae-Hoon
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Abstract
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Effects of Opuntia ficus indica (OFI) extracts on ethanol-induced psychomotor alterations were studied using Sprague-Dawley rats orally administered 4 g/kg of ethanol (EtOH group) or distilled water (control group). An OFI-group received OFI extracts (50, 100, and 200 mg/kg) 30 min prior to EtOH administration. Behavioral and hematological tests were evaluated 1, 2, 4, and 8 h after EtOH administration. Electroencephalogram (EEG) assessment was also performed. EtOH significantly (p<0.001) induced psychomotor alterations (reduced locomotion, balance, coordination, muscle strength, and tolerance to cold), compared with control group rats. Pre-treatment with OFI extracts alleviated alterations and also inhibited elevation of blood ethanol levels. EEG (percent of total power for delta, theta, alpha, and beta) results for OFI group rats were similar to control rats, indicating a countering of EtOHinduced EEG changes. Extracts of OFI can be effective for alleviation of psychomotor alterations induced by EtOH administration.
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KEYWORD
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Opuntia ficus indica, ethanol, psychomotor alteration, electroencephalogram
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